Generic Xenical Orlistat Weight Loss Obesity Drug Dosage Review

Generic Xenical (Orlistat, Xenical® equivalent)
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Weight Loss Drug :
Xenical is a gastrointestinal lipase inhibitor used in the management of obesity in adult and adolescent patients age 12 and older. This medicine may be used during the weight loss phase or following weight loss to assist in weight management. Generic Xenical works by inhibiting the digestion of fats from the diet, and should be used with a reduced-calorie diet.

Orlistat (marketed as a prescription under the trade name Xenical by Roche in most countries, or over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States), also known as tetrahydrolipstatin, is a drug designed to treat obesity.

Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. It is intended for use in conjunction with a physician-supervised reduced-calorie diet. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to simplicity and stability, orlistat rather than lipstatin was developed into an anti-obesity drug.

Xenical is used together with a reduced-calorie diet and weight maintenance to treat obesity in people with certain risk factors, such as diabetes, high blood pressure, and high cholesterol or triglycerides.

Do not take Xenical if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight or obese. You should not take Xenical if you are allergic to orlistat, if you are pregnant, or if you have gallbladder problems or chronic malabsorption syndrome (an inability to absorb food and nutrients properly).

Avoid a diet that is high in fat. High-fat meals taken in combination with Xenical can increase your risk of unpleasant side effects on your stomach or intestines.

Take Xenical exactly as directed on the label, or as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended.

Xenical comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Take Xenical during or within 1 hour after a meal that contains some fat (no more than 30% of the calories for that meal). Xenical is usually taken 3 times daily.

If you skip a meal or you eat a meal that does not contain any fat, skip your Xenical dose for that meal.

Your doctor may recommend you take vitamin and mineral supplements while you are taking Xenical. This medication can make it harder for your body to absorb fat-soluble vitamins, such as vitamins A, D, E, and K. Follow your doctor's instructions about the type of multi-vitamin or mineral supplement to use.

Take your vitamin or supplement at bedtime, or at least 2 hours before or after you take Xenical.

Store Xenical at room temperature away from moisture and heat. Keep the bottle tightly closed. Throw away any unused Xenical after the expiration date on the medicine label has passed.

What happens if I miss a dose?

Take the missed dose as soon as you remember, but no more than 1 hour after eating a meal. If it has been more than an hour since your last meal, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

If you miss a meal, or if you have a meal without fat, you can skip your dose of Xenical for that meal also.

What should I avoid while taking Xenical?

Avoid a diet that is high in fat. High-fat meals taken in combination with Xenical can increase your risk of unpleasant side effects on your stomach or intestines.

Xenical side effects

The following side effects occur commonly with the use of Xenical. They are the natural effects of orlistat's fat-blocking action and are actually signs that the medication is working properly. These side effects are usually temporary and may lessen as you continue treatment with Xenical:

oily spotting in your undergarments;
oily or fatty stools;
orange or brown colored oil in your stool;
gas with discharge, an oily discharge;

loose stools, or an urgent need to go to the bathroom, inability to control bowel movements;
an increased number of bowel movements;
stomach pain, nausea, vomiting, diarrhea, rectal pain; or

weakness, dark urine, clay-colored stools, itching, loss of appetite, or jaundice (yellowing of the skin or eyes).

Other side effects that may occur while taking Xenical include:

problems with your teeth or gums;
cold symptoms such as stuffy nose, sneezing, cough;
fever, chills, sore throat, flu symptoms;
headache, back pain; or
mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Xenical Dosing Information

Usual Adult Xenical Dose for Obesity:

120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.

Usual Pediatric Dose for Obesity:

12 years or older:
120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.

What other drugs will affect Xenical?

Tell your doctor about all other medications you use, especially:

cyclosporine (Gengraf, Neoral, Sandimmune);
a vitamin or mineral supplement that contains beta carotene or vitamin E;
levothyroxine (Synthroid, Levoxyl, Levothroid);
insulin or diabetes medications you take by mouth;
digoxin (digitalis, Lanoxin, Lanoxicaps); or
a blood thinner such as warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with Xenical. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

 

 

 

 

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